Rita K. Schmutzler, Björn Schmitz-Luhn, Bettina Borisch, Peter Devilee, Diana Eccles, Per Hall, Judith Balmaña, Stefanie Boccia, Peter Dabrock, Günter Emons, Wolfgang Gaissmaier, Jacek Gronwald, Stefanie Houwaart, Stefan Huster, Karin Kast, Alexander Katalinic, Sabine C. Linn, Sowmiya Moorthie, Paul Pharoah, Kerstin Rhiem, Tade Spranger, Dominique Stoppa-Lyonnet, Johannes Jozef Marten van Delden, Christiane Woopen, Marc van den Bulcke
- \(\bf Background:\) Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action.
\(\bf Summary:\) Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept.
MetadatenAuthor: | Rita K. SchmutzlerGND, Björn Schmitz-LuhnGND, Bettina BorischGND, Peter DevileeGND, Diana EcclesGND, Per HallGND, Judith BalmañaGND, Stefanie BocciaGND, Peter DabrockGND, Günter EmonsGND, Wolfgang GaissmaierGND, Jacek GronwaldGND, Stefanie HouwaartGND, Stefan HusterGND, Karin KastGND, Alexander KatalinicORCiDGND, Sabine C. LinnGND, Sowmiya MoorthieGND, Paul PharoahGND, Kerstin RhiemGND, Tade SprangerGND, Dominique Stoppa-LyonnetGND, Johannes Jozef Marten van DeldenGND, Christiane WoopenGND, Marc van den BulckeGND |
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URN: | urn:nbn:de:hbz:294-93900 |
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DOI: | https://doi.org/10.1159/000517182 |
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Parent Title (English): | Breast care |
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Subtitle (English): | complementing screening for early disease detection by a learning screening based on risk factors |
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Publisher: | Karger |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/10/27 |
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Date of first Publication: | 2021/08/12 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Tag: | Breast cancer; ELSI ethical, legal, social implications; Evidencegenerating care; Risk-adjusted prevention |
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Volume: | 17 |
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Issue: | 2 |
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First Page: | 208 |
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Last Page: | 223 |
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Note: | Dieser Beitrag ist aufgrund einer konsortialen Lizenz frei zugänglich. |
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Institutes/Facilities: | Lehrstuhl für Öffentliches Recht, Sozial- und Gesundheitsrecht und Rechtsphilosophie |
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open_access (DINI-Set): | open_access |
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faculties: | Juristische Fakultät |
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Licence (German): | Konsortiale Lizenz |
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