Bernhard Wörmann, Carsten Bokemeyer, Thomas Burmeister, Claus-Henning Köhne, Matthias Schwab, Dirk Arnold, Jens-Uwe Blohmer, Markus Borner, Sara Brucker, Ingolf Cascorbi, Thomas Decker, Maike de Wit, Andreas Dietz, Hermann Einsele, Wolfgang Eisterer, Gunnar Folprecht, Wolfgang Hilbe, Jürgen Hoffmann, Wolfgang Knauf, Volker Kunzmann, Carlo R. Largiadèr, Sylvie Lorenzen, Diana Lüftner, Markus Moehler, Markus M. Nöthen, Christian P. Pox, Anke Claudia Reinacher-Schick, Anton Scharl, Brigitte Schlegelberger, Thomas Seufferlein, Marianne Sinn, Matthias Stroth, Ingo Tamm, Lorenz Trümper, Martin Wilhelm, Ewald Wöll, Ralf-Dieter Hofheinz
- \(\bf Background:\) 5-Fluorouracil (FU) is one of the most commonly used cytostatic drugs in the systemic treatment of cancer. Treatment with FU may cause severe or life-threatening side effects and the treatment-related mortality rate is 0.2–1.0%.
\(\bf Summary:\) Among other risk factors associated with increased toxicity, a genetic deficiency in dihydropyrimidine dehydrogenase (DPD), an enzyme responsible for the metabolism of FU, is well known. This is due to variants in the DPD gene (DPYD). Up to 9% of European patients carry a DPD gene variant that decreases enzyme activity, and DPD is completely lacking in approximately 0.5% of patients. Here we describe the clinical and genetic background and summarize recommendations for the genetic testing and tailoring of treatment with 5-FU derivatives. The statement was developed as a consensus statement organized by the German Society for Hematology and Medical Oncology in cooperation with 13 medical associations from Austria, Germany, and Switzerland.
\(\bf Key Messages:\) (i) Patients should be tested for the 4 most common genetic DPYD variants before treatment with drugs containing FU. (ii) Testing forms the basis for a differentiated, risk-adapted algorithm with recommendations for treatment with FU-containing drugs. (iii) Testing may optionally be supplemented by therapeutic drug monitoring.
MetadatenAuthor: | Bernhard WörmannGND, Carsten BokemeyerGND, Thomas BurmeisterORCiDGND, Claus-Henning KöhneGND, Matthias SchwabGND, Dirk ArnoldORCiDGND, Jens-Uwe BlohmerORCiDGND, Markus BornerGND, Sara BruckerGND, Ingolf CascorbiORCiDGND, Thomas DeckerGND, Maike de WitGND, Andreas DietzGND, Hermann EinseleORCiDGND, Wolfgang EistererGND, Gunnar FolprechtORCiDGND, Wolfgang HilbeGND, Jürgen HoffmannORCiDGND, Wolfgang KnaufGND, Volker KunzmannGND, Carlo R. LargiadèrGND, Sylvie LorenzenGND, Diana LüftnerGND, Markus MoehlerGND, Markus M. NöthenORCiDGND, Christian P. PoxGND, Anke Claudia Reinacher-SchickORCiDGND, Anton ScharlGND, Brigitte SchlegelbergerORCiDGND, Thomas SeufferleinGND, Marianne SinnGND, Matthias StrothGND, Ingo TammGND, Lorenz TrümperGND, Martin WilhelmGND, Ewald WöllGND, Ralf-Dieter HofheinzGND |
---|
URN: | urn:nbn:de:hbz:294-93414 |
---|
DOI: | https://doi.org/10.1159/000510258 |
---|
Parent Title (English): | Oncology research and treatment |
---|
Subtitle (English): | a consensus paper |
---|
Publisher: | Karger |
---|
Place of publication: | Basel |
---|
Document Type: | Article |
---|
Language: | English |
---|
Date of Publication (online): | 2022/10/14 |
---|
Date of first Publication: | 2020/10/23 |
---|
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
---|
Tag: | 5-Fluorouacil; Capecitabine; Dihydropyrimidine dehydrogenase mutation; Genetic testing; Tegafur |
---|
Volume: | 43 |
---|
Issue: | 11 |
---|
First Page: | 628 |
---|
Last Page: | 636 |
---|
Note: | Dieser Beitrag ist aufgrund einer nationalen Lizenz frei zugänglich. |
---|
Institutes/Facilities: | Katholisches Klinikum Bochum, Hämatologie, Onkologie und Palliativmedizin |
---|
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
---|
open_access (DINI-Set): | open_access |
---|
Licence (German): | Nationale Lizenz |
---|