- \(\bf Background:\) Posttherapeutic mucositis is a common secondary effect of oral cancer treatment. Mucositis affects the oral mucosa, which leads to specific physical impairments in oral function and a negative impact on quality of life.
\(\bf Objective:\) To evaluate the impairments associated with oral mucositis and their impact on posttherapeutic quality of life.
\(\bf Methods:\) A retrospective analysis was conducted on 1,652 patients treated for oral cancer during the multicenter rehabilitation study of the German-Austrian-Swiss Cooperative Group on Tumors of the Maxillofacial Region (DÖSAK), which included 43 clinics from Germany, Austria, and Switzerland. The analysis was based on questionnaires filled out by patients following treatment.
\(\bf Results:\) Approximately 10% of 1,652 patients included in our study had physical or psychological impairments due to increased posttreatment oral mucositis; this was mainly due to adjuvant radiotherapy or radiochemotherapy administered. Oral mucositis was significantly associated with specific physical impairments, especially xerostomia and pain (\(\it p\) = 0.000), which required supportive care and analgesia (\(\it p\) = 0.000). Additionally, impaired ingestion and speech significantly led to psychological disorders such as public avoidance behavior and social isolation (p = 0.001). Depressive coping of disease (\(\it p\) = 0.001) and concomitant depressive tendencies (\(\it p\) = 0.004) were highly associated with mucositis, which was accompanied by diminished general condition (\(\it p\) = 0.001), bleak future prospects (\(\it p\) = 0.006), and a reduction in quality of life (\(\it p\) = 0.002).
\(\bf Conclusion:\) Minimizing mucositis-related impairments should be a main effort in oral cancer treatment to optimize patient outcome and improve quality of life after therapy.
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