Beyond the usual suspects
- Hepatitis E virus infections are the leading cause of viral hepatitis in humans, contributing to an estimated 3.3 million symptomatic cases and almost 44,000 deaths annually. Recently, HEV infections have been found to result in chronic liver infection and cirrhosis in severely immunocompromised patients, suggesting the possibility of HEV-induced hepatocarcinogenesis. While HEV-associated formation of HCC has rarely been reported, the expansion of HEV's clinical spectrum and the increasing evidence of chronic HEV infections raise questions about the connection between HEV and HCC. The present review summarizes current clinical evidence of the relationship between HEV and HCC and discusses mechanisms of virus-induced HCC development with regard to HEV pathogenesis. We further elucidate why the development of HEV-induced hepatocellular carcinoma has so rarely been observed and provide an outlook on possible experimental set-ups to study the relationship between HEV and HCC formation.
| Author: | Mara KlöhnORCiDGND, Jil Alexandra SchraderORCiDGND, Yannick BrüggemannGND, Daniel Matthias TodtORCiDGND, Eike SteinmannORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-86429 |
| DOI: | https://doi.org/10.3390/cancers13225867 |
| Parent Title (English): | Cancers |
| Subtitle (English): | Hepatitis E virus and its implications in hepatocellular carcinoma |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/02/23 |
| Date of first Publication: | 2021/11/22 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | carcinogenesis; chronic infection; hepatitis E virus; hepatocellular carcinoma; oncovirus |
| Volume: | 13 |
| Issue: | 22, Article 5867 |
| First Page: | 5867-1 |
| Last Page: | 5867-19 |
| Institutes/Facilities: | Institut für Hygiene und Mikrobiologie, Abteilung für Molekulare und Medizinische Virologie |
| Medizinische Fakultät, Abteilung für Molekulare und Medizinische Virologie | |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
