Biological functions of the intrinsically disordered N-terminal domain of the prion protein
- The mammalian prion protein (\(PrP^{C}\)) is composed of a large intrinsically disordered N-terminal and a structured C-terminal domain, containing three alpha-helical regions and a short, two-stranded beta-sheet. Traditionally, the activity of a protein was linked to the ability of the polypeptide chain to adopt a stable secondary/tertiary structure. This concept has been extended when it became evident that intrinsically disordered domains (IDDs) can participate in a broad range of defined physiological activities and play a major functional role in several protein classes including transcription factors, scaffold proteins, and signaling molecules. This ability of IDDs to engage in a variety of supramolecular complexes may explain the large number of \(PrP^{C}\)-interacting proteins described. Here, we summarize diverse physiological and pathophysiological activities that have been described for the unstructured N-terminal domain of \(PrP^{C}\). In particular, we focus on subdomains that have been conserved in evolution.
| Author: | Stella A. PolidoORCiDGND, Janine KampsORCiDGND, Jörg TatzeltORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-85088 |
| DOI: | https://doi.org/10.3390/biom11081201 |
| Parent Title (English): | Biomolecules |
| Subtitle (English): | a possible role of liquid–liquid phase separation |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/01/06 |
| Date of first Publication: | 2021/08/12 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | intrinsically disordered; liquid-liquid phase separation; neurodegeneration; prion; stress protection |
| Volume: | 11 |
| Issue: | 8, Article 1201 |
| First Page: | 1201-1 |
| Last Page: | 1201-11 |
| Institutes/Facilities: | Institut für Biochemie und Pathobiochemie, Abteilung Biochemie Neurodegenerativer Erkrankungen |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Chemie, Kristallographie, Mineralogie |
| open_access (DINI-Set): | open_access |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
