In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

  • SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially newly emerging coronaviruses, numerous pre-clinical cell culture techniques have progressively been used, which allow the study of SARS-CoV-2 pathogenesis, basic replication mechanisms, and drug efficiency in the most authentic context. Hence, this review was designed to summarize and discuss currently used in vitro and ex vivo cell culture systems and will illustrate how these systems will help us to face the challenges imposed by the current SARS-CoV-2 pandemic.

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Metadaten
Author:Natalie HeinenORCiDGND, Mara KlöhnORCiDGND, Eike SteinmannORCiDGND, Stephanie PfänderORCiDGND
URN:urn:nbn:de:hbz:294-82454
DOI:https://doi.org/10.3390/v13050792
Parent Title (English):Viruses
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/07/28
Date of first Publication:2021/04/28
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
SARS-CoV-2; air–liquid interface; cell culture; ex vivo lung; human airway epithelial cell culture; human lung organoids; in vitro lung model; lung-on-a-chip
Volume:13
Issue:5, Article 792
First Page:792-1
Last Page:792-17
Note:
Article Processing Charge funded by the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Institut für Hygiene und Mikrobiologie, Abteilung für Molekulare und Medizinische Virologie
Institut für Hygiene und Mikrobiologie
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International

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