Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for rare gynecologic indications
- \(\bf Background\) Peritoneal metastasis (PM) in patients with breast (BC) and endometrial cancer (EC) is rare and treatment options are limited. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has demonstrated efficacy against PM from various cancers, but its efficacy in BC/EC patients is unknown. \(\bf Methods\) Retrospective cohort study of patients with PM from BC/EC undergoing PIPAC with doxorubicin 1.5 mg/m\(^{2}\) and cisplatin 7.5 mg/m\(^{2}\). Data were collected within an international prospective PIPAC registry. Study outcomes were microscopic tumor regression grade (TRG), survival, adverse events (CTCAE), and quality of life (QoL). \(\bf Results\) 150 PIPAC procedures in 44 patients (BC/EC = 28/16; mean age 58.8 \(\pm\) 10.1 and 63.2 \(\pm\) 10.1 years, respectively) were analyzed. The mean number of PIPACs per patient was 3 (range 0–9) and 3.5 (range 0–10), respectively. Primary/secondary non-access occurred in 4/3 of 150 (5%) procedures. PIPAC induced objective tumor regression as demonstrated by repetitive PM biopsies in 73% (32/44) of patients. Peri- and postoperative CTCAE grade 3 and 4 complications were observed in 12/150 (8%) of procedures. No grade 5 event was observed. After a median follow up of 5.7 (IQR 2.7–13.0) months, overall median survival was 19.6 (95% CI: 7.8–31.5) months (from first PIPAC). QoL indicators (general health, nausea, fatigue, constipation, pain, dyspnea, social, cognitive, emotional, and physical functioning) all improved or were maintained throughout PIPAC treatments. \(\bf Conclusions\) Repetitive intraperitoneal chemotherapy with PIPAC is feasible and safe in patients with PM from BC and EC. PIPAC induces significant histological regression of PM while maintaining QoL.
Author: | Günther RezniczekORCiDGND, Urs PabstGND, Omar ThaherGND, Clemens TempferORCiDGND |
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URN: | urn:nbn:de:hbz:294-81529 |
DOI: | https://doi.org/10.1186/s12885-020-07627-1 |
Parent Title (English): | BMC Cancer |
Subtitle (English): | peritoneal metastases from breast and endometrial cancer |
Publisher: | BioMed Central LtD |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/06/17 |
Date of first Publication: | 2020/11/19 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Breast cancer; Endometrial cancer; PIPAC; Peritoneal metastasis; Tumor regression |
Volume: | 20 |
Issue: | Artikel 1122 |
First Page: | 1122-1 |
Last Page: | 1122-11 |
Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | Marienhospital Herne, Klinik für Frauenheilkunde und Geburtshilfe |
Marienhospital Herne, Chirurgische Klinik | |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |