Struktur-Biomarker zur Früherkennung von Morbus Alzheimer
- Alzheimer’s disease cannot be cured today. In addition to a drug, a predictive blood biomarker is urgently needed to identify high-risk subjects in early cognitively less impaired stages. Here, a biomarker is presented that uses the secondary structure distribution of A\(\beta\)-peptides in blood measured by the immuno-infrared sensor. Using this structure-based biomarker clinical conversion of symptomless subjects at baseline were predicted in a follow-up study 14 years before manifestation.
| Author: | Julia StockmannGND, Klaus GerwertORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-80500 |
| DOI: | https://doi.org/10.1007/s12268-020-1381-7 |
| Parent Title (German): | BIOspektrum |
| Publisher: | Springer Nature |
| Place of publication: | Berlin |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2021/04/29 |
| Date of first Publication: | 2020/05/14 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Volume: | 26 |
| First Page: | 259 |
| Last Page: | 261 |
| Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
| Institutes/Facilities: | Lehrstuhl für Biophysik |
| Zentrum für Protein-Diagnostik (PRODI) | |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
| open_access (DINI-Set): | open_access |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (German): |  Creative Commons - CC BY 4.0 - Namensnennung 4.0 International |
