The molecular mechanisms associated with the physiological responses to inflammation and oxidative stress in cardiovascular diseases

  • The complex physiological signal transduction networks that respond to the dual challenges of inflammatory and oxidative stress are major factors that promote the development of cardiovascular pathologies. These signaling networks contribute to the development of age-related diseases, suggesting crosstalk between the development of aging and cardiovascular disease. Inhibition and/or attenuation of these signaling networks also delays the onset of disease. Therefore, a concept of targeting the signaling networks that are involved in inflammation and oxidative stress may represent a novel treatment paradigm for many types of heart disease. In this review, we discuss the molecular mechanisms associated with the physiological responses to inflammation and oxidative stress especially in heart failure with preserved ejection fraction and emphasize the nature of the crosstalk of these signaling processes as well as possible therapeutic implications for cardiovascular medicine.

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Metadaten
Author:Saltanat ZhazykbayevaGND, Steffen PabelGND, Andreas MüggeORCiDGND, Samuel SossallaGND, Nazha HamdaniGND
URN:urn:nbn:de:hbz:294-80316
DOI:https://doi.org/10.1007/s12551-020-00742-0
Parent Title (English):Biophysical Reviews
Publisher:Springer Nature
Place of publication:Berlin
Document Type:Article
Language:English
Date of Publication (online):2021/04/23
Date of first Publication:2020/07/21
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Cardiovascular diseases; Heart failure; Molecular mechanisms; Proteins modification; Signaling pathways
Volume:2020
Issue:12
First Page:947
Last Page:968
Note:
Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich.
Institutes/Facilities:St. Josef-Hospital Bochum, Medizinische Klinik II, Klinik für Kardiologie
Institut für Pharmakologie und Toxikologie, Abteilung für klinische Pharmakologie
Institut für Physiologie
Katholisches Klinikum Bochum, Molekulare und Experimentelle Kardiologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
faculties:Medizinische Fakultät
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International

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