Little helpers or mean rogue—role of microglia in animal models of amyotrophic lateral sclerosis
- Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative diseases, causing degeneration of both upper and lower motor neurons in the central nervous system (CNS). ALS patients suffer from hyperreflexia, spasticity, paralysis and muscle atrophy and typically die due to respiratory failure 1–5 years after disease onset. In addition to the degeneration of motor neurons on the cellular level, ALS has been associated with neuroinflammation, such as microgliosis. Microglial activation in ALS can either be protective or degenerative to the neurons. Among others, mutations in superoxide dismutase 1 (SOD1), chromosome 9 open reading frame 72 (C9Orf72), transactive response DNA binding protein (TDP) 43 and vacuolar protein sorting-associated protein 54 (VPS54) genes have been associated with ALS. Here, we describe the dual role and functionality of microglia in four different in vivo ALS models and search for the lowest common denominator with respect to the role of microglia in the highly heterogeneous disease of ALS.
| Author: | Hilal CihankayaORCiDGND, Carsten TheißORCiDGND, Veronika MatschkeORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-80285 |
| DOI: | https://doi.org/10.3390/ijms22030993 |
| Parent Title (English): | International journal of molecular sciences |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/04/22 |
| Date of first Publication: | 2021/01/20 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | Open Access Fonds ALS; chromosome 9 open reading frame 72; microglial activation; neuroinflammation; superoxide dismutase 1; transactive response DNA binding protein 43; wobbler mouse |
| Volume: | 22 |
| Issue: | 3, Artikel993 |
| First Page: | 993-1 |
| Last Page: | 993-27 |
| Note: | Article Processing Charge funded by the Open Access Publication Fund of Ruhr-Universität Bochum. |
| Institutes/Facilities: | Institut für Anatomie, Abteilung für Cytologie |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
