Host defense peptides as effector molecules of the innate immune response

  • Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses. Both antimicrobial and/or immunomodulatory activities are an integral part of the process of innate immunity, which itself has many of the hallmarks of successful anti-infective therapies, namely rapid action and broad-spectrum antimicrobial activities. This gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections. This review details the role and activities of these peptides, and examines their applicability as development candidates for use against bacterial infections.

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Metadaten
Author:Lars SteinsträßerGND, Ursula M. KraneburgGND, Tobias HirschGND, Marco KestingGND, Hans-Ulrich SteinauGND, Frank JacobsenGND, Sammy al- BennaORCiDGND
URN:urn:nbn:de:hbz:294-78181
DOI:https://doi.org/10.3390/ijms10093951
Parent Title (English):International journal of molecular sciences
Subtitle (English):a sledgehammer for drug resistance?
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/02/02
Date of first Publication:2009/09/09
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:antimicrobial peptides; bacterial infection; host defense peptides; inflammation; innate immunity; sepsis
Volume:10
Issue:9
First Page:3951
Last Page:3970
Institutes/Facilities:Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Klinik für Plastische Chirurgie und Schwerbrandverletzte
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 3.0 Unported - Attribution 3.0 Unported

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