Functional and cognitive capacity differ in dystonic motor subtypes when compared to choreatic and hypokinetic-rigid motor subtypes in Huntington's disease
- \(\bf Background\) Motor phenotypes in Huntington's disease vary manifold. Phenotype classification is essential to adapt treatment. The aim of this study was to classify a dystonic subtype closer. \(\bf Methods\) A total of 7,512 manifest ENROLL‐HD participants were subdivided into mainly choreatic (\(\it N\) = 606), dystonic (\(\it N\) = 402), and hypokinetic‐rigid (\(\it N\) = 369) subjects. Cognitive (verbal fluency, symbol digit, stroop color, trail making, Mini‐Mental State Examination), functional (total functional capacity, Independence Scale), and psychiatric (problem behaviors assessment, Hospital Anxiety and Depression Scale) performance was evaluated at baseline visit. \(\bf Results\) Symptoms onset for dystonic were similar to hypokinetic‐rigid, but earlier compared to choreatic subjects (\(\it p\) < .001). Cognition was better in both groups compared to hypokinetic rigid (all \(\it p\) < .001). Functionality differed between all groups (all \(\it p\) < .001). Differences remained (all \(\it p\) < .001) after controlling for CAP score, CAG, age, disease duration, and education. \(\bf Conclusions\) Motor subtypes differ in functional and cognitive capacities but less in psychiatric. We identified better cognitive and functional capacities and similar onsets in predominant dystonic compared to hypokinetic‐rigid patients.
Author: | Jannis AchenbachORCiDGND, Sarah Maria von HeinGND, Carsten SaftORCiDGND |
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URN: | urn:nbn:de:hbz:294-78101 |
DOI: | https://doi.org/10.13154/294-7810 |
Parent Title (English): | Brain and behavior |
Publisher: | Wiley-VCH Verlag |
Place of publication: | Hoboken, New Jersey |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/02/01 |
Date of first Publication: | 2020/06/12 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Huntington's disease; dystonia; movement disorders |
Volume: | 10 |
Issue: | 8, Artikel e01704 |
First Page: | e01704-1 |
Last Page: | e01704-7 |
Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
Note: | DOI der Original-Publikation: https://onlinelibrary.wiley.com/doi/10.1002/brb3.1704 |
Institutes/Facilities: | St. Josef-Hospital Bochum, Neurologische Klinik |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |