Armin Zittermann, Jana Barbara Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Jochen Börgermann, Heiner Berthold, Stefan Pilz, Ioanna Gouni-Berthold, Jan Gummert
- \(\textit {Background/Aims:}\) We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease. \(\textit {Methods:}\) We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L (vitamin D group: \(\it n\) = 80; placebo group: \(\it n\) = 81), who received a daily vitamin \(D_{3}\) supplement of 4,000 IU for 3 years. We assessed between-group differences of the lipid parameters total-cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides, and the VC markers fetuin-A and non-phosphorylated undercarboxylated matrix gla protein (MGP) at study termination, with adjustment for baseline values. \(\textit {Results:}\) Lipid parameters, the percentage of patients with dyslipoproteinemia, and VC markers did not differ significantly between groups at study termination (\(\it p\) values: 0.395–0.939). Likewise, vitamin D achieved no significant treatment effect on these markers in subgroup analyses in patients with 25OHD concentrations < 30 nmol/L, nonusers of lipid-lowering drugs, or diabetic patients (\(\it p\) values: 0.245–0.998). \(\textit {Conclusion:}\) Our data indicate that vitamin D does not improve the lipid profile and does not influence the calcification inhibitors fetuin-A and non-phosphorylated undercarboxylated MGP in patients with advanced heart failure.
MetadatenAuthor: | Armin ZittermannORCiDGND, Jana Barbara ErnstGND, Sylvana ProkopGND, Uwe FuchsGND, Jens DreierGND, Joachim KuhnGND, Cornelius KnabbeGND, Jochen BörgermannGND, Heiner BertholdGND, Stefan PilzGND, Ioanna Gouni-BertholdGND, Jan GummertORCiDGND |
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URN: | urn:nbn:de:hbz:294-73831 |
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DOI: | https://doi.org/10.1159/000495662 |
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Parent Title (English): | Annals of nutrition & metabolism |
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Subtitle (English): | the effect of vitamin D on mortality in heart failure trial |
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Publisher: | Karger |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2020/08/05 |
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Date of first Publication: | 2018/12/14 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Tag: | Cardiovascular risk markers; Dyslipoproteinemia; Fetuin-A; Matrix-gla-protein; Vitamin D |
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Volume: | 74 |
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Issue: | 1 |
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First Page: | 62 |
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Last Page: | 68 |
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Note: | Dieser Beitrag ist aufgrund einer nationalen Lizenz frei zugänglich. |
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Institutes/Facilities: | Herz- und Diabeteszentrum NRW, Klinik für Thorax- und Kardiovaskularchirurgie |
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open_access (DINI-Set): | open_access |
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Licence (German): | Nationale Lizenz |
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