mTOR
- The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level. mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer. Therefore, the selective and context-dependent inhibition of mTOR activity itself might come into the focus as molecular target to prevent severe diseases and possibly to extend life span. This review provides a general introduction to the molecular composition and physiologic function of mTOR complexes as part of the Special Issue “2018 Select Papers by \(\textit {Cells’}\) Editorial Board Members”.
| Author: | Fahd BoutoujaGND, Christian M. StiehmGND, Harald W. PlattaGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-67403 |
| DOI: | https://doi.org/10.3390/cells8010018 |
| Parent Title (English): | Cells |
| Subtitle (English): | a cellular regulator interface in health and disease |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2019/11/19 |
| Date of first Publication: | 2019/01/02 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | aging; autophagy; cancer; kinase; mTOR; phosphorylation |
| Volume: | 8 |
| Issue: | 1 |
| First Page: | 18-1 |
| Last Page: | 18-23 |
| Institutes/Facilities: | Institut für Biochemie und Pathobiochemie, Abteilung für Systembiochemie, Arbeitsgruppe Biochemie Intrazellulärer Transportprozesse |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
