Selective serotonin reuptake inhibitors for the prevention of post-stroke depression
- There are controversial data on the efficacy and safety profile of selective serotonin reuptake inhibitors (SSRIs) to prevent post-stroke depression (PSD). We performed a systematic search in MEDLINE and SCOPUS databases to identify randomized-controlled trials questioning the use of early SSRI therapy in the post-stroke population and its effect on PSD incidence. We included 6 studies with 6560 participants. We extracted the data on PSD occurrence in association with the treatment arm (SSRI versus placebo), as reported by each study. For safety analysis, we extracted the information on adverse events. A random-effects model was used to calculate the pooled relative risk estimates. Early SSRI therapy was associated with a significant reduction of PSD occurrence compared to placebo (10.4% versus 13.8%; relative risk: 0.75 [95% CI, 0.66–0.86]; absolute risk reduction: 3.4%). SSRI therapy increases the risk of bone fracture (RR 2.28 [95% CI, 1.58–3.30]) and nausea (RR 2.05 [95% CI, 1.10–3.82]) in the post-stroke population. Considering the risk-benefit ratio of early SSRI therapy in the post-stroke population, future research should identify high-risk patients for PSD to improve the risk-benefit consideration of this therapy for use in clinical practice.
Author: | Daniel RichterORCiDGND, Jeyanthan Charles JamesGND, Andreas EbertGND, Aristeidis H. KatsanosORCiDGND, Lisa Mazul-WachGND, Quirin RulandGND, Ralf GoldORCiDGND, Georg JuckelORCiDGND, Christos KrogiasORCiDGND |
---|---|
URN: | urn:nbn:de:hbz:294-71149 |
DOI: | https://doi.org/10.3390/jcm10245912 |
Parent Title (English): | Journal of clinical medicine |
Subtitle (English): | a systematic review and meta-analysis |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/03/25 |
Date of first Publication: | 2021/12/16 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds post-stroke depression; serotonin reuptake inhibitor; stroke |
Volume: | 10 |
Issue: | 24, Article 5912 |
First Page: | 5912-1 |
Last Page: | 5912-8 |
Note: | Article Processing Charge funded by the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | Katholisches Klinikum Bochum, Neurologie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |