Murine transcription factor Math6 is a regulator of placenta development
- The murine basic helix-loop-helix transcription (bHLH) factor mouse atonal homolog 6 (Math6) is expressed in numerous organs and supposed to be involved in several developmental processes. However, so far neither all aspects nor the molecular mechanisms of Math6 function have been explored exhaustively. To analyze the in vivo function of Math6 in detail, we generated a constitutive knockout (KO) mouse (\(\it {Math6}\)\(^{−}/^{−}\)) and performed an initial histological and molecular biological investigation of its main phenotype. Pregnant \(\it {Math6}\)\(^{−}/^{−}\) females suffer from a disturbed early placental development leading to the death of the majority of embryos independent of the embryonic \(\it {Math6}\) genotype. A few placentas and fetuses survive the severe uterine hemorrhagic events at late mid-gestation (E13.5) and subsequently develop regularly. However, these fetuses could not be born due to obstructions within the gravid uterus, which hinder the birth process. Characterization of the endogenous spatiotemporal \(\it {Math6}\) expression during placenta development reveals that Math6 is essential for an ordered decidualization and an important regulator of the maternal-fetal endocrine crosstalk regulating endometrial trophoblast invasion and differentiation. The strongly disturbed vascularization observed in the maternal placenta appears as an additional consequence of the altered endocrine status and as the main cause for the general hemorrhagic crisis.
Author: | Marion BöingGND, Beate Brand-SaberiORCiDGND, Markus NapireiORCiDGND |
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URN: | urn:nbn:de:hbz:294-64076 |
DOI: | https://doi.org/https://doi.org/10.1038/s41598-018-33387-x |
Parent Title (English): | Scientific reports |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2019/05/03 |
Date of first Publication: | 2018/10/09 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Disease model; Intrauterine growth |
Volume: | 8 |
First Page: | 14997-1 |
Last Page: | 14997-14 |
Note: | Scientific reports, Bd. 8.2018, Artikelnummer 14997 |
Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | Institut für Anatomie, Abteilung für Anatomie und Molekulare Embryologie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |