Prediagnostic detection of mesothelioma by circulating calretinin and mesothelin
- Malignant mesothelioma (MM) is strongly associated with a previous asbestos exposure. To improve timely detection of MM in asbestos workers, better screening tools – like minimally-invasive biomarkers – are desirable. Between 2008 and 2018 2,769 patients with benign asbestos-related diseases were recruited to participate in annual screens. Using a nested case-control design the protein markers calretinin and mesothelin were determined by enzyme-linked immunosorbent assays in prediagnostic plasma samples of 34 MM cases as well as 136 matched controls from the cohort. Conditional on a pre-defined specificity of 98% for calretinin and 99% for mesothelin the markers reached individual sensitivities of 31% and 23%, respectively, when including the incident cases with samples taken between one and 15 months before diagnosis. The combination of both markers increased the sensitivity to 46% at 98% specificity. Marker complementation increased with earlier sampling. The marker combination improves the sensitivity of the individual markers, indicating a useful complementation and suggesting that additional markers may further improve the performance. This is the first prospective cohort study to evaluate a detection of MM by calretinin and its combination with mesothelin up to about a year before clinical diagnosis. Whether an earlier diagnosis will result in reduced mortality has yet to be demonstrated.
Author: | Georg JohnenORCiDGND, Katarzyna BurekGND, Katharina WichertGND, Beate PeschORCiDGND, Daniel G. WeberORCiDGND, Martin LehnertGND, Swaantje CasjensORCiDGND, Olaf HagemeyerGND, Dirk TaegerORCiDGND, Thomas BrüningORCiDGND, Irina RaikoGND |
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URN: | urn:nbn:de:hbz:294-64033 |
DOI: | https://doi.org/10.1038/s41598-018-32315-3 |
Parent Title (English): | Scientific Reports |
Subtitle (German): | a case-control comparison nested into a prospective cohort of asbestos-exposed workers |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2019/05/02 |
Date of first Publication: | 2018/09/25 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds Cancer screening; Diagnostic markers; Mesothelioma; Risk factors |
Volume: | 8 |
First Page: | 14321-1 |
Last Page: | 14321-11 |
Note: | Scientific Reports, Bd. 8.2018, Artikelnummer 14321 |
Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
faculties: | Medizinische Fakultät |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |