CXCR4/SDF1 signalling promotes sensory neuron clustering \(\textit {in vitro}\)
- During the development of the peripheral nervous system, a subgroup of neural crest cells migrate away from the neural tube and coalesce into clusters of sensory neurons (ganglia). Mechanisms involved in the formation of the dorsal root ganglia (DRG) from neural crest cells are currently unclear. Mice carrying mutations in \(\textit {Cxcr4}\), which is known to control neural crest migration, exhibit malformed DRG. In order to investigate this phenomenon, we modelled sensory neuron differentiation \(\textit {in vitro}\) by directing the differentiation of human induced pluripotent stem cells into sensory neurons under SDF1 (agonist), AMD3100 (antagonist) or control conditions. There we could show a marked effect on the clustering activity of the neurons \(\textit {in vitro}\), suggesting that \(\textit {CXCR4}\) signalling is involved in facilitating DRG condensation.
| Author: | Daniel Terheyden-KeighleyGND, Xiaoqing ZhangGND, Beate Brand-SaberiORCiDGND, Carsten TheißORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-63609 |
| DOI: | https://doi.org/10.1242/bio.035568 |
| Parent Title (English): | Biology Open |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2019/03/29 |
| Date of first Publication: | 2018/09/19 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | CXCL12; Condensation; DRG; Open Access Fonds |
| Volume: | 7 |
| Issue: | 9 |
| First Page: | bio035568-1 |
| Last Page: | bio035568-6 |
| Note: | Biology Open; Bd. 7.2018, Artikelnummer bio035568 |
| Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
| Institutes/Facilities: | Institut für Anatomie, Abteilung für Cytologie |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 3.0 Unported - Attribution 3.0 Unported |
