Are circulating microRNAs suitable for the early detection of malignant mesothelioma?
- \(\bf Objective:\) Malignant mesothelioma is an aggressive cancer of the serous membranes. For the detection of the tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating biomarkers miR-132-3p, miR-126-3p, and miR-103a-3p were analyzed in a nested case–control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. \(\bf Results:\) Using prediagnostic plasma samples collected in median 8.9 months prior the clinical diagnosis miR-132-3p, miR-126-3p, and miR-103a-3p revealed 0% sensitivity on a defined specificity of 98%. Thus, the analyzed miRNAs failed to detect the cancer in prediagnostic samples, showing that they are not feasible for the early detection of malignant mesothelioma. However, the miRNAs might still serve as possible markers for prognosis and response to therapy, but this needs to be analyzed in appropriate studies.
| Author: | Daniel G. WeberORCiDGND, Alexander BrikGND, Swaantje CasjensORCiDGND, Katarzyna BurekGND, Martin LehnertGND, Beate PeschORCiDGND, Dirk TaegerORCiDGND, Thomas BrüningORCiDGND, Georg JohnenORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-63255 |
| DOI: | https://doi.org/10.1186/s13104-019-4113-7 |
| Parent Title (English): | BMC research notes |
| Subtitle (English): | Results from a nested case–control study |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2019/03/08 |
| Date of first Publication: | 2019/02/11 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | Open Access Fonds Biomarker; Blood; Cancer; Liquid biopsies; Marker; Mesothelioma; MicroRNA; Negative results; Null results; Prediagnostic |
| Volume: | 12 |
| First Page: | 77-1 |
| Last Page: | 77-6 |
| Note: | BMC Research Notes, 12.2019, 77 |
| Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
| Institutes/Facilities: | Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
