Resolution of cheyne-stokes respiration after treatment of heart failure with Sacubitril/Valsartan
- Sleep-disordered breathing (SDB) is highly prevalent in patients with heart failure (HF), and is known to be associated with a worse prognosis. The severity of central sleep apnea is thought to mirror cardiac dysfunction. The novel angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril has been shown to improve HF, but a relationship between treatment with ARNi and the severity of SDB has not yet been investigated. We report the case of a 71-year-old male with HF and SDB. Treatment with sacubitril/valsartan was associated with improved cardiac function, as shown by a reduction in the level of N-terminal prohormone of brain natriuretic peptide from 3,249 to 1,720 pg/mL, and an improvement in left-ventricular ejection fraction from 30 to 35%. This was accompanied by a marked reduction in the apnea-hypopnea index (from 41 to 19/h). To the best of our knowledge, this is the first case to document parallel improvements in HF and SDB after the initiation of ARNi treatment.
| Author: | Henrik FoxORCiDGND, Thomas BitterGND, Dieter HorstkotteGND, Olaf OldenburgGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-60685 |
| DOI: | https://doi.org/10.1159/000455118 |
| Parent Title (English): | Cardiology |
| Subtitle (English): | a first case report |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2018/07/26 |
| Date of first Publication: | 2017/02/09 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | Open Access Fonds Angiotensin receptor-neprilysin inhibitor; Central sleep apnea; Cheyne-Stokes respiration; Heart failure; Sacubitril/Valsartan; Sleep-disordered breathing |
| Volume: | 137 |
| Issue: | 2 |
| First Page: | 96 |
| Last Page: | 99 |
| Note: | Dieser Beitrag ist aufgrund einer nationalen Lizenz frei zugänglich. |
| Institutes/Facilities: | Herz- und Diabeteszentrum NRW, Kardiologische Klinik |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| open_access (DINI-Set): | open_access |
| faculties: | Medizinische Fakultät |
| Licence (German): |  Nationale Lizenz |
