Glial dysfunction and the involvement of spinal cord and olfactory system in genetic mouse models of Parkinson's disease
Gliale Dysfunktion und Beteiligung des Rückenmarkes und des olfaktorischen Systems in genetischen Mausmodellen des Morbus Parkinson
- Parkinson´s disease (PD) is a common neurodegenerative disorder of unknown cause. The key feature of PD is the preferential loss of dopaminergic neurons in the substantia nigra pars compacta. Recent literature suggests that initial pathologic manifestations could be found in the spinal cord and the olfactory bulb. Although PD is traditionally thought of as a disease of neurons several observations indicate that astrocytes are active contributors to the initiation or progression of PD. To elucidate the PD pathogenesis different mouse lines carrying PD-inducing gene mutations have been generated. One line carries a homozygous deletion of parkin Exon3 and two transgenic lines overexpress human doubly mutated \(\alpha\)-synuclein (A30P, A53T). In summary, this work strengthens the hypotheses that the spinal cord could and the olfactory bulb could be early contributors to the disease progression in PD. Furthermore, mitochondrial damage in glial cells could play a key role in the progression of PD.
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| Author: | Sonja Veronika MendritzkiGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-32196 |
| Referee: | Hermann LübbertORCiDGND, Stefan WieseORCiDGND |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2011/10/26 |
| Date of first Publication: | 2011/10/26 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Fakultät für Biologie und Biotechnologie |
| Date of final exam: | 2011/06/08 |
| Creating Corporation: | Fakultät für Biologie und Biotechnologie |
| GND-Keyword: | Mitochondrium; Gliazelle; Parkinson-Krankheit; Astrozyt; Rückenmark |
| Institutes/Facilities: | Lehrstuhl für Tierphysiologie |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
