RANTES and fractalkine
- Findings of inflammatory infiltrates in vascular lesions of lungs displaying pulmonary arterial hypertension (PAH) emphasize the possible influence of inflammatory mechanisms under this condition. Chemokine RANTES and chemokine fractalkine are known to be important chemoattractants for monocytes and T-cells. We hypothesize that both chemokines could promote leucocytic recruitment in lungs of patients with PAH. The study demonstrates elevated expression of RANTES and fractalkine mRNA, as well as protein product in lung samples from PAH-patients as compared to controls, using \(\underline {RT-PCR}\), \(\underline {\textit {in situ hybridization}}\), and \(\underline {immunohistochemistry}\). Our experiments provide evidence for increased RANTES and fractalkine production in lungs of patients suffering from severe PAH. They support the concept that inflammatory mechanisms play a role in the natural history of PAH.
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| Author: | Peter DorfmüllerGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-5382 |
| Subtitle (English): | the role of the chemokines in pulmonary arterial hypertension |
| Referee: | Klaus-Michael MüllerGND, Marc HumbertORCiDGND |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2002/08/14 |
| Date of first Publication: | 2002/08/14 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Medizinische Fakultät |
| Date of final exam: | 2002/05/28 |
| Creating Corporation: | Medizinische Fakultät |
| GND-Keyword: | Pulmonale Hypertonie; Chemokine; RANTES; Endothel; Entzündliches Infiltrat |
| Institutes/Facilities: | Institut für Pathologie |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| faculties: | Medizinische Fakultät |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
