Effects of omega 3 fatty acids on vascular function in subjects with Type 2 diabetes mellitus
- \(\bf Objective:\) We investigated the effects of n-3 FAs on vascular function in subjects with type 2 diabetes mellitus. \(\bf Method:\) In a double-blind, placebo-controlled, randomized, crossover manner, 34 subjects received daily 2 g either n-3 FAs or placebo for 6 weeks. After each therapy, we measured macrovascular (FMD) and microvascular (reactive hyperemia) function fasting as well as following a high fat meal. \(\bf Results:\) Fasting FMD remained unchanged following n-3 FAs or placebo. Postprandial FMD decreased after placebo with 38% - an effect significantly reduced by n-3 FAs supplementation (13%). Postprandial reactive hyperemia remained unchanged after placebo, whereas it improved significantly after n-3 FAs supplementation (maximum increase 27%). Adiponectin and leptin didn´t significantly change after placebo or n-3 FAs. \(\bf Conclusions:\) Our results suggest a protective effect of n-3 FAs on vascular function.
Download full text files
Additional Services
| Author: | Simona NandreanGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-47988 |
| Referee: | Diethelm TschöpeGND, Horst Harald KleinGND |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2016/04/19 |
| Date of first Publication: | 2016/04/19 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Granting Institution: | Ruhr-Universität Bochum, Medizinische Fakultät |
| Date of final exam: | 2015/11/05 |
| Creating Corporation: | Medizinische Fakultät |
| GND-Keyword: | Fischöl; Omega-3-Fettsäuren; Vasodilatation; Hyperämie; Blutgefäß |
| Institutes/Facilities: | Herz- und Diabeteszentrum NRW |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
| faculties: | Medizinische Fakultät |
| Licence (German): |  Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |
